| Source: | Rabbit | Gene Id: | 5562/5563 | 
| Isotype: | / | Swiss Prot: | Q13131/P54646 | 
| purity: | Affinity chromatography | 
| Background: | 
| The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq | 
| Reactivity | Human, Mouse, Rat | 
| Tested applications | IHC | 
| Clonality | Polyclonal Antibody | 
| Calculated MW | 62 kDa | 
| Recommended Dilutions | 
                                    
                                     IHC 1:50-1:100 
                                    
                                    
                                    
                                    
                                    
                                 | 
                            
| Immunogen | A synthetic peptide corresponding to residues surrounding S485/S491 of human PRKAA1/PRKAA2 | 
| Storage | Store at -20°C in PBS (without Mg2+ and Ca2+), 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide).Avoid freeze/thaw cycles. | 
| Synonym | AMPK, AMPKa1, MGC33776, MGC57364 | 
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