| Source: | Rabbit | Gene Id: | 2550 | 
| Isotype: | / | Swiss Prot: | Q9UBS5 | 
| purity: | Immunoaffinity chromatography | 
| Background: | 
| Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates multiple transcript variants. [provided by RefSeq | 
| Reactivity | Bovine, Dog, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Orangutan, Pig, Rat | 
| Tested applications | IHC | 
| Clonality | Polyclonal Antibody | 
| Calculated MW | 95,130 kDa | 
| Recommended Dilutions | 
                                    
                                     IHC 7-13 ug/mL 
                                    
                                    
                                    
                                    
                                    
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| Immunogen | A synthetic peptide corresponding to 15 amino acid at N-terminus of human GABBR1 | 
| Storage | Store at 4°C. For long term storage store at -20°C in PBS (0.1% sodium azide).Avoid freeze/thaw cycles. | 
| Synonym | FLJ92613, GABAB(1e), GABABR1, GABBR1-3, GPRC3A, dJ271M21.1.1, dJ271M21.1.2, hGB1a | 
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