| No | Size | Price | Availability | |
| ARP23286-11 | 50ul | 1500.00 | In Stock |  |
| ARP23286-11 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 23286 |
| Isotype: | IgG | Swiss Prot: | Q8IX03 |
| purity: | Antigen affinity purification |
| Background: |
| The Hippo pathway is an important evolutionarily conserved signaling pathway that controls organ size and tumor suppression by inhibiting cell proliferation and promoting apoptosis (1,2). An integral function of the Hippo pathway is to repress the activity of YAP (Yes-associated protein), a proposed oncogene whose activity is regulated by phosphorylation and subcellular localization (3,4). Recent studies have identified KIBRA as a novel regulator of Hippo signaling (5-7). KIBRA has been shown to regulate Hippo signaling through its interaction with tumor suppressors Merlin (Mer) and Expanded (Ex) in Drosophila (7) and by associating with large tumor suppressors LATS1 and LATS2 in humans (8). In humans, KIBRA is predominantly expressed in the kidney and brain (9) and has been shown to play a role in hippocampus-related memory performance (10-12). Recent studies have shown that phosphorylation of KIBRA is highest during mitosis and is controlled by aurora kinase and protein phosphatase 1 (13). |
| Reactivity | Human |
| Tested applications | WB IHC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 135 kDa |
| Recommended Dilutions |
WB 1:250-1:500
IHC 1:500-1:1000
IF 1-4 ug/mL
|
| Immunogen | A recombinant protein corresponding to amino acids of human WWC1 |
| Storage | Store at 4°C. For long term storage store at -20°C in PBS, pH 7.5 (40% glycerol, 0.02% sodium azide).Avoid freeze/thaw cycles. |
| Synonym | FLJ10865, FLJ23369, KIAA0869, KIBRA |
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