| No | Size | Price | Availability | |
| ARP6510-12 | 50ul | 1500.00 | In Stock |  |
| ARP6510-12 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 6510 |
| Isotype: | IgG | Swiss Prot: | Q15758 |
| purity: | Antigen affinity purification |
| Background: |
| Sodium-dependent neutral amino acid transporter type 2 (ASCT2 or SLC1A5) is a neutral amino acid transporter that regulates the uptake of essential amino acids in conjunction with the SLC7A5 bilateral transporter (1,2). ASCT2 appears to be the major glutamine transporter in hepatoma cells and is thought to provide essential amino acids needed for tumor growth (3). Additional evidence suggests that ASCT2 plays a role in activating mTORC1 signaling and is required to suppress autophagy (4,5). Cell surface ASCT2 serves as a receptor for several mammalian interference retroviruses associated with cases of infectious immunodeficiency; variation in a small region of an extracellular loop (ECL2) may be responsible for species-specific differences in receptor function (6). |
| Reactivity | Human |
| Tested applications | IHC IF |
| Clonality | Polyclonal Antibody |
| Calculated MW | 49,75 kDa |
| Recommended Dilutions |
IHC 1:50-1:200
IF 1-4 ug/mL
|
| Immunogen | A recombinant protein corresponding to amino acids of human SLC1A5 |
| Storage | Store at 4°C. For long term storage store at -20°C in PBS, pH 7.5 (40% glycerol, 0.02% sodium azide).Avoid freeze/thaw cycles. |
| Synonym | AAAT, ASCT2, ATBO, FLJ31068, M7V1, M7VS1, R16, RDRC |
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