| No | Size | Price | Availability | |
| ARP91584-11 | 50ul | 1500.00 | In Stock |  |
| ARP91584-11 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 91584 |
| Isotype: | IgG | Swiss Prot: | Q9HCM2 |
| purity: | Antigen affinity purification |
| Background: |
| Class 3 secreted semaphorin (Sema3A) is a chemorepellent that acts upon a wide variety of axons. As such, it induces a dramatic redistribution and depolymerization of actin filaments that results in growth cone collapse. Plexins are single membrane-spanning signaling proteins encompassing Plexin A1, A2, A3, and A4. Plexins form a complex with neuropilin-1 and -2 and the cell adhesion protein L1 to form a functional semaphorin receptor (1,2). The GTPase Rnd1 binds to the cytoplasmic domain of Plexin A1 to trigger cytoskeletal collapse. In contrast, the GTPase RhoD blocks Rnd1-mediated Plexin A1 activation and repulsion of sympathetic axons by Sema3A (3). |
| Reactivity | Human |
| Tested applications | IHC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 212 kDa |
| Recommended Dilutions |
IHC 1:50-1:200
|
| Immunogen | A recombinant protein corresponding to amino acids of human PLXNA4 |
| Storage | Store at 4°C. For long term storage store at -20°C in PBS, pH 7.5 (40% glycerol, 0.02% sodium azide).Avoid freeze/thaw cycles. |
| Synonym | DKFZp434G0625, DKFZp566O0546, FAYV2820, FLJ35026, FLJ38287, KIAA1550, PLEXA4, PLXNA4A, PLXNA4B, PRO34003 |
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