| No | Size | Price | Availability | |
| ARP64855-13 | 50ul | 1500.00 | In Stock |  |
| ARP64855-13 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 64855 |
| Isotype: | IgG | Swiss Prot: | Q96TA1 |
| purity: | Antigen affinity purification |
| Background: |
| FAM129B/Niban-like protein 1 (family with sequence similarity 129, member B) belongs to a poorly characterized family of Niban proteins that also includes FAM129A/Niban and FAM129C/Niban-like protein 2. FAM129A/Niban is implicated in the ER stress response and is upregulated at the protein level in thyroid carcinoma (1,2). FAM129C/Niban-like protein 2 is preferentially expressed in B-cells and is one of five biomarkers upregulated in whole blood from patients with colorectal carcinoma (3,4). FAM129B is broadly expressed and has been shown to be a downstream target of B-Raf in melanoma cells (5). Though FAM129B does not appear to regulate cell growth and division, phosphorylation of FAM129B by B-Raf is essential for the invasive potential of melanoma and non-melanoma cell lines (5). Deletion of FAM129B in melanoma cells significantly impairs B-Raf/MEK/Erk-dependent invasion into the extracellular matrix (5). |
| Reactivity | Human |
| Tested applications | WB |
| Clonality | Polyclonal Antibody |
| Calculated MW | 95 kDa |
| Recommended Dilutions |
WB 1:250-1:500
|
| Immunogen | A recombinant protein corresponding to amino acids of human FAM129B |
| Storage | Store at 4°C. For long term storage store at -20°C in PBS, pH 7.5 (40% glycerol, 0.02% sodium azide).Avoid freeze/thaw cycles. |
| Synonym | C9orf88, DKFZP434H0820, FLJ13518, FLJ22151, FLJ22298, MEG-3, OC58, bA356B19.6 |
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