Source: | Rabbit | Gene Id: | 23607 |
Isotype: | / | Swiss Prot: | Q9Y5K6 |
purity: | Antigen affinity purification |
Background: |
This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease. [provided by RefSeq |
Reactivity | Human, Mouse, Rat |
Tested applications | WB IHC IF |
Clonality | Polyclonal Antibody |
Calculated MW | 130 kDa |
Recommended Dilutions |
WB 1:250-1:500
IHC 1:200-1:500
IF 1-4 ug/mL
|
Immunogen | A recombinant protein corresponding to amino acids of human CD2AP |
Storage | Store at 4°C. For long term storage store at -20°C in PBS, pH 7.5 (40% glycerol, 0.02% sodium azide).Avoid freeze/thaw cycles. |
Synonym | CMS, DKFZp586H0519 |
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