| No | Size | Price | Availability | |
| ARP11160-11 | 50ul | 1500.00 | In Stock |  |
| ARP11160-11 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 11160 |
| Isotype: | / | Swiss Prot: | O94905 |
| purity: | Antigen affinity purification |
| Background: |
| Erlin-1 and erlin-2 (SPFH1 and SPFH2) are SPFH domain-containing proteins that belong to the prohibitin family (1,2). The N-termal domain of erlin proteins contains ER-targeting sequences responsible for their translocation to the endoplasmic reticulum (ER) (3). In the ER, erlin-1 and erlin-2 specifically associate with the detergent resistant lipid raft microdomain of the membrane (3). Erlin-1 may be involved in dentritic cell activation (4) and erlin-2 has been shown to regulate the ER-associated degradation (ERAD) pathway by interacting with endogenous substrates and resulting in their polyubiquitination and degradation (5). |
| Reactivity | Human |
| Tested applications | WB IHC IF |
| Clonality | Polyclonal Antibody |
| Calculated MW | 43 kDa |
| Recommended Dilutions |
WB 1:250-1:500
IHC 1:500-1:1000
IF 1-4 ug/mL
|
| Immunogen | A recombinant protein corresponding to amino acids of human ERLIN2 |
| Storage | Store at 4°C. For long term storage store at -20°C in PBS, pH 7.5 (40% glycerol, 0.02% sodium azide).Avoid freeze/thaw cycles. |
| Synonym | C8orf2, Erlin-2, MGC87072, SPFH2 |
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