| No | Size | Price | Availability | |
| ARP5664-11 | 50ul | 1500.00 | In Stock |  |
| ARP5664-11 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 5664 |
| Isotype: | / | Swiss Prot: | P49810 |
| purity: | Affinity purification |
| Background: |
| Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq |
| Reactivity | Human, Rat |
| Tested applications | WB IHC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 23 kDa |
| Recommended Dilutions |
WB 1 ug/mL
IHC 1 ug/mL
|
| Immunogen | A synthetic peptide corresponding to internal region of human PSEN2 |
| Storage | Store at -20°C on dry atmosphere.After reconstitution with 200 uL of deionized water and concentration will be 500 ug/mL, store at -20°C or lower. |
| Synonym | AD3L, AD4, PS2, STM2 |
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