| No | Size | Price | Availability | |
| ARP57534-11 | 50ul | 1500.00 | In Stock |  |
| ARP57534-11 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 57534 |
| Isotype: | / | Swiss Prot: | Q86YT6 |
| purity: | Affinity purification |
| Background: |
| Mindbomb homolog 1 (MIB1) is an E3 ligase that facilitates the ubiquitination and the subsequent endocytosis of the Notch ligands, Delta and Jagged (1,2). MIB1 appears to promote the ubiquitination and degradation of death-associated protein kinase (DAPK1) in vitro (3). Expression of MIB1 is seen in both adult and embryonic murine tissues (4). Recently, MIB1 was reported to regulate the extrinsic cell death pathway by binding to cellular FLICE-like inhibitory proteins (cFLIP-L and cFLIP-S), which reduces the interaction of caspase-8 with cFLIP and leads to cell death (5). MIB1 is also involved in T and marginal zone B (MZB) cell development in the lymphopoietic niches (6). |
| Reactivity | Human |
| Tested applications | WB IHC ELISA IF |
| Clonality | Polyclonal Antibody |
| Calculated MW | 110 kDa |
| Recommended Dilutions |
WB 1:100-1:500
IHC 1:50-1:100
IF 1:20-1:100
|
| Immunogen | A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human MIB1 |
| Storage | Store at 4°C. For long term storage store at -20°C in PBS (0.09% sodium azide).Avoid freeze/thaw cycles. |
| Synonym | DIP-1, DKFZp686I0769, DKFZp761M1710, FLJ90676, MGC129659, MGC129660, MIB, ZZANK2, ZZZ6 |
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