| No | Size | Price | Availability | |
| ARP2322P-11 | 50ul | 1500.00 | In Stock |  |
| ARP2322P-11 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 2322 |
| Isotype: | / | Swiss Prot: | P36888 |
| purity: | Affinity purification |
| Background: |
| This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq |
| Reactivity | Human, Mouse, Rat |
| Tested applications | IHC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 130 kDa |
| Recommended Dilutions |
IHC 1:50-1:100
|
| Immunogen | A synthetic phosphopeptide corresponding to residues surrounding Y591 of human FLT3 |
| Storage | Store at 4°C. For long term storage store at -20°C in 20 mM PBS, 0.15 M NaCl, pH 7.2 (0.01% sodium azide).Avoid freeze/thaw cycles. |
| Synonym | CD135, FLK2, STK1 |
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