DCBLD2 Rabbit Polyclonal Antibody
No Size Price Availability  
ARP131566-11 50ul 1500.00 In Stock
ARP131566-11 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 131566
Isotype: / Swiss Prot: Q96PD2
purity: Affinity purification
Background:
DCBLD2 (discoidin, CUB and LCCL domain-containing 2; also known as ESDN and CLCP1) is a type I transmembrane protein that is structurally similar to neuropilin family proteins and contains the longest known amino-terminal secretory signal sequence among eukaryotic proteins (1). Highly expressed in nerve bundles, vascular smooth muscle cells and upregulated following vascular injury, DCBLD2 may be involved in a wide range of functions in the nervous and vascular systems (1,2). Studies have found DCBLD2 to be upregulated in several types of lung cancer with an especially high frequency in metastatic lesions and lymph node metastasis, implicating a role in the process of tumor progression and metastatic capability (3). DCBLD2 has also been identified as part of a complex EGF phosphotyrosine signaling network, serving as a novel tyrosine phosphorylation target of EGF signaling in human cancer cells (4).
Reactivity Human, Mouse, Rat
Tested applications WB
Clonality Polyclonal Antibody
Calculated MW 120 kDa
Recommended Dilutions
WB 1:500-1:1000
Immunogen A synthetic peptide corresponding to amino acids 399-416 of human DCBLD2
Storage Store at 4°C. For long term storage store at -20°C in PBS (0.02% sodium azide).Avoid freeze/thaw cycles.
Synonym CLCP1, ESDN
This product is for research use only, not for diagnostic or therapeutic use!

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