| No | Size | Price | Availability | |
| ARP5884P-31 | 50ul | 1500.00 | In Stock |  |
| ARP5884P-31 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 5884 |
| Isotype: | IgG | Swiss Prot: | O75943 |
| purity: | Affinity purification |
| Background: |
| The human checkpoint protein Rad17 and its fission and budding yeast orthologues (Schizosaccharomyces pombe Rad17 and Saccharomyces cerevisiae Rad24, respectively) are involved in the activation of checkpoint signals in response to DNA damage or disruption of DNA synthesis (1-4). Treatment of human cells with genotoxic agents induces ATM/ATR-dependent phosphorylation of Rad17 at Ser635 and Ser645. Rad17 phosphorylation is a critical early event during checkpoint signaling in DNA-damaged cells (5-7). |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB |
| Clonality | Polyclonal Antibody |
| Calculated MW | 80 kDa |
| Recommended Dilutions | |
| Immunogen | A synthetic peptide corresponding to residues surrounding Ser645 of human Rad17 protein |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | CCYC, R24L, RAD24, HRAD17, RAD17SP |
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