| No | Size | Price | Availability | |
| ARP2017P-31 | 50ul | 1500.00 | In Stock |  |
| ARP2017P-31 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 2017 |
| Isotype: | / | Swiss Prot: | Q14247 |
| purity: | Affinity purification |
| Background: |
| This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IHC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 80-85 kDa |
| Recommended Dilutions | |
| Immunogen | A synthetic phosphopeptide corresponding to residues surrounding Tyr421 of human cortactin |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | EMS1 |
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