| No | Size | Price | Availability | |
| ARP5321P-31 | 50ul | 1500.00 | In Stock |  |
| ARP5321P-31 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 5321 |
| Isotype: | / | Swiss Prot: | P47712 |
| purity: | Affinity purification |
| Background: |
| Cytosolic phospholipase A2 (cPLA2) is a ubiquitously distributed enzyme that catalyzes the hydrolysis of the sn-2 acyl bond of glycerolipids to produce lysophospholipids and release arachidonic acid (1). cPLA2 has been implicated in diverse cellular responses such as mitogenesis, differentiation, inflammation and cytotoxicity (1). Calcium binding to the amino-terminal CalB domain of cPLA2 promotes the translocation of cPLA2 from cytosol to membrane, where cPLA2 cleaves arachidonic acid from natural membrane (2). Phosphorylation of cPLA2 by MAPK (p42/44 and p38) at Ser505 (3,4) and Ser727 (5) stimulates its catalytic activity. |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IHC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 95 kDa |
| Recommended Dilutions | |
| Immunogen | A synthetic phosphopeptide corresponding to residues surrounding Ser505 of human cPLA2 |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | Cytosolic phospholipase A2, cPLA2, Phospholipase A2 group IVA, Lysophospholipase, PLA2G4, CPLA2, PLA2G4A |
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