| No | Size | Price | Availability | |
| ARP1741-11 | 50ul | 1500.00 | In Stock |  |
| ARP1741-11 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 1741 |
| Isotype: | / | Swiss Prot: | P07858 |
| purity: | Affinity purification |
| Background: |
| This gene encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. This cotransporter mediates sodium and chloride reabsorption in the distal convoluted tubule. Mutations in this gene cause Gitelman syndrome, a disease similar to Bartter's syndrome, that is characterized by hypokalemic alkalosis combined with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. This cotransporter is the target for thiazide diuretics that are used for treating high blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IF |
| Clonality | Polyclonal Antibody |
| Calculated MW | 102 kDa |
| Recommended Dilutions |
WB 1:1000
|
| Immunogen | A recombinant protein corresponding to SLC12A3 N-terminus (amino acids 74-95) |
| Storage | Store at 4°C. For long term storage store at -20°C in PBS, 50% glycerol and 0.09% sodium azide.Avoid freeze/thaw cycles. |
| Synonym | FLJ96318, NCCT, TSC |
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