| No | Size | Price | Availability | |
| ARP51651-11 | 50ul | 1500.00 | In Stock |  |
| ARP51651-11 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 51651 |
| Isotype: | / | Swiss Prot: | Q9Y3E5 |
| purity: | Affinity purification |
| Background: |
| Bit1 is a mitochondrial protein discovered as a regulator of anoikis, a process of apoptosis triggered by the loss of cell adhesion to the extracellular matrix (1,2). Like several other mitochondrial apoptotic regulators (Cytochrome c, Smac, HtrA2, AIF, EndoG), Bit1 is released into the cytoplasm during apoptosis (1,3). Cytoplasmic Bit1 associates with the Groucho family of transcriptional regulator AES (1,4). Interaction between Bit1 and AES promotes apoptosis, and this complex is suppressed by integrin mediated cell attachment. |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB ICC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 19,21 kDa |
| Recommended Dilutions |
WB 1-2 ug/mL
|
| Immunogen | A synthetic peptide corresponding to N-terminus 15 amino acids of human PTRH2 |
| Storage | Store at 4°C for three months. For long term storage store at -20°C in PBS (0.02% sodium azide).Avoid freeze/thaw cycles. |
| Synonym | BIT1, CGI-147, FLJ32471, PTH2 |
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