WWTR1 Rabbit Polyclonal Antibody
No Size Price Availability  
ARP25937-11 50ul 1500.00 In Stock
ARP25937-11 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 25937
Isotype: / Swiss Prot: Q9GZV5
purity: Affinity purification
Background:
CBP (CREB-binding protein) and p300 are highly conserved and functionally related transcriptional co-activators that associate with transcriptional regulators and signaling molecules, integrating multiple signal transduction pathways with the transcriptional machinery (1,2). CBP/p300 also contain histone acetyltransferase (HAT) activity, allowing them to acetylate histones and other proteins (2). Phosphorylation of p300 at Ser89 by PKC represses its transciptional acitivity, and phosphorylation at the same site by AMPK disrupts the association of p300 with nuclear receptors (3,4). Ser1834 phosphorylation of p300 by Akt disrupts its association with C/EBPβ (5). Growth factors induce phosphorylation of CBP at Ser437, which is required for CBP recruitment to the transcription complex (6). CaM kinase IV phosphorylates CBP at Ser302, which is required for CBP-dependent transcriptional activation in the CNS (7). The role of acetylation of CBP/p300 is of particular interest (2,8). Acetylation of p300 at Lys1499 has been demonstrated to enhance its HAT activity and affect a wide variety of signaling events (9).
Reactivity Human, Mouse, Rat
Tested applications WB IHC IP IF
Clonality Polyclonal Antibody
Calculated MW 50 kDa
Recommended Dilutions
WB 1:1000-1:5000
IF 1:50-1:200
ICC 1:50-1:200
Immunogen A synthetic peptide corresponding to human WWTR1
Storage Store at -20°C or -80°C in PBS (10% glycerol, 0.02% sodium azide).Avoid freeze/thaw cycles.
Synonym DKFZp586I1419, TAZ
This product is for research use only, not for diagnostic or therapeutic use!

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