| No | Size | Price | Availability | |
| ARP5599P-11 | 50ul | 1500.00 | In Stock |  |
| ARP5599P-11 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 5599 |
| Isotype: | / | Swiss Prot: | P45983 |
| purity: | Affinity purification |
| Background: |
| The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB ELISA |
| Clonality | Polyclonal Antibody |
| Calculated MW | 46,54 kDa |
| Recommended Dilutions |
WB 1:200
|
| Immunogen | A synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding T183/Y185 of human MAPK8 |
| Storage | Store at 4°C in PBS (0.2% gelatin, 0.1% sodium azide). Do not freeze. |
| Synonym | JNK, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1 |
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