| No | Size | Price | Availability | |
| ARP51330-11 | 50ul | 1500.00 | In Stock |  |
| ARP51330-11 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 51330 |
| Isotype: | / | Swiss Prot: | Q9NP84 |
| purity: | Affinity purification |
| Background: |
| The receptor for TWEAK, fibroblast growth factor-inducible 14 (Fn14), is a member of the TNF superfamily of receptors thought to be involved in cell growth, adhesion and migration (1). Its expression is regulated by a number of different growth factors (1,2). Elevated expression is also seen in some cancers including hepatocellular carcinomas (3), glioblastomas (4), and pancreatic cancer (5). The receptor contains a binding site for members of the TNFR-associated factor (TRAF) family that promotes the activation of NF-κB (1,6). Recent studies have suggeted some therapeutic potential of TWEAK and its receptor signaling in regards to autoimmunity and cancer treatment (7-9). |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB |
| Clonality | Polyclonal Antibody |
| Calculated MW | 14-17 kDa |
| Recommended Dilutions | |
| Immunogen | A synthetic peptide corresponding to amino acids 104-118 of human TNFRSF12A |
| Storage | Store at 4°C. For long term storage store at -20°C in PBS (0.05% BSA, 0.05% sodium azide).Avoid freeze/thaw cycles. |
| Synonym | CD266, FN14, TWEAKR |
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