| Deltex (DTX) encodes a putative E3 ubiquitin ligase first identified from Drosophila and shown to modulate Notch signaling. Several mammalian Deltex homologs have been isolated, all containing a pair of WWE repeats, a proline-rich region, and a Ring-finger domain. Deltex binds to the ankyrin-repeat domain of Notch and is capable of regulating Notch signaling positively or negatively in different systems. In addition, Deltex can also form homo-multimers. While Deltex has been implicated in Notch signaling regulation of lymphocyte development, this signal modifier may also have a transcriptional function independent of Notch. |
