| No | Size | Price | Availability | |
| AMP92140-11 | 50ul | 1500.00 | In Stock |  |
| AMP92140-11 | 100ul | 2000.00 | In Stock | |
| Source: | Mouse | Gene Id: | 92140 |
| Isotype: | / | Swiss Prot: | Q86UE4 |
| purity: | Affinity purification |
| Background: |
| Lyric/AEG-1 (Astrocyte Elevated Gene 1)/MTDH (Metadherin) was identified as a tight junction (TJ) protein based on its localization to TJ proteins in polarized epithelium. Differential subcellular localization and overexpression of Lyric/AEG-1/MTDH has been seen in multiple human cancers. Lyric/AEG-1/MTDH is involved in signaling pathways related to various cellular functions including proliferation and apoptosis/survival, and its alteration in cancer is associated with poor prognosis. In breast cancer, increased Lyric/AEG-1/MTDH may confer increased chemoresistance as well as metastasis. Lyric/AEG-1/MTDH expression is important in signaling and disease progression of hepatocellular carcinoma (HCC) and glioblastoma multiforme (GBM). |
| Reactivity | Human |
| Tested applications | WB IF |
| Clonality | Polyclonal Antibody |
| Calculated MW | 65, 75 kDa |
| Recommended Dilutions | |
| Immunogen | MTDH (NP_8489271, 1 aa ~ 582 aa) full-length human protein |
| Storage | Store at -20°C or lower in PBS(pH 7.4). Avoid freeze/thaw cycles. |
| Synonym | 3D3, AEG-1, AEG1, LYRIC |
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