LIN28 Mouse Polyclonal Antibody
No Size Price Availability  
AMP79727-11 50ul 1500.00 In Stock
AMP79727-11 100ul 2000.00 In Stock
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Source: Mouse Gene Id: 79727
Isotype: / Swiss Prot: Q9H9Z2
purity: Affinity purification
Background:
LIN28A and LIN28B are conserved, developmentally regulated RNA binding proteins that inhibit the processing and maturation of the let-7 family of miRNAs. The let-7 miRNAs have been implicated in repression of oncogenes such as Ras, Myc, and HMGA2. It has recently been shown that upregulation of LIN28A and LIN28B in primary human tumors and human cancer cell lines is correlated with downregulation of let-7 miRNAs. LIN28 genes are reported to be involved in primordial germ cell development and germ cell malignancy. In addition, allelic variation in LIN28B is associated with regulating the timing of puberty in humans. Overexpression of LIN28A, in conjunction with Oct-4, Sox2, and Nanog, can reprogram human fibroblasts to pluripotent, ES-like cells.
Reactivity Human
Tested applications WB IF
Clonality Polyclonal Antibody
Calculated MW 26 kDa
Recommended Dilutions
Immunogen LIN28 (AAH28566, 1 aa ~ 209 aa) full-length human protein
Storage Store at -20°C or lower in 50% glycerol. Avoid freeze/thaw cycles.
Synonym CSDD1, FLJ12457, LIN-28, LIN28A, ZCCHC1
This product is for research use only, not for diagnostic or therapeutic use!

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