| No | Size | Price | Availability | |
| AMP4000-11 | 50ul | 1500.00 | In Stock |  |
| AMP4000-11 | 100ul | 2000.00 | In Stock | |
| Source: | Mouse | Gene Id: | 4000 |
| Isotype: | / | Swiss Prot: | P02545 |
| purity: | Affinity purification |
| Background: |
| The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Through alternate splicing, this gene encodes three type A lamin isoforms. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. |
| Reactivity | Human |
| Tested applications | WB IF |
| Clonality | Polyclonal Antibody |
| Calculated MW | 73.04 kDa |
| Recommended Dilutions | |
| Immunogen | LMNA (NP_7338211, 1 aa ~ 664 aa) full-length human protein |
| Storage | Store at -20°C or lower in PBS(pH 7.4). Avoid freeze/thaw cycles. |
| Synonym | CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, HGPS, IDC, LDP1, LFP, LGMD1B, LMN1, LMNC, PRO1 |
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