| No | Size | Price | Availability | |
| ARP114548-61 | 50ul | 1500.00 | In Stock |  |
| ARP114548-61 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 114548 |
| Isotype: | IgG | Swiss Prot: | Q96P20 |
| purity: | Affinity purification |
| Background: |
| This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. |
| Reactivity | Human, Rat |
| Tested applications | WB IHC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 118 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
IHC 1:50-1:200
|
| Immunogen | A recombinant protein of human NLRP3 |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 5431% glycerol. Avoid freeze/thaw cycles. |
| Synonym | FCU, MWS, FCAS, Cias1, Mmig1, NALP3, Pypaf1, AII/AVP, AGTAVPRL |
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