| No | Size | Price | Availability | |
| ARP5884-62 | 50ul | 1500.00 | In Stock |  |
| ARP5884-62 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 5884 |
| Isotype: | IgG | Swiss Prot: | O75943 |
| purity: | Affinity purification |
| Background: |
| The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IHC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 77 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
IHC 1:50-1:200
|
| Immunogen | A recombinant protein of human RAD17 |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 6237% glycerol. Avoid freeze/thaw cycles. |
| Synonym | CCYC, R24L, RAD24, HRAD17, RAD17SP |
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