| No | Size | Price | Availability | |
| ARP387893-61 | 50ul | 1500.00 | In Stock |  |
| ARP387893-61 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 387893 |
| Isotype: | IgG | Swiss Prot: | Q9NQR1 |
| purity: | Affinity purification |
| Background: |
| Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specificallymonomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tagfor epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role inthe silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance ofproper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis.Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382',leading to repress p53/TP53-target genes. |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IHC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 43 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
IHC 1:50-1:200
|
| Immunogen | A recombinant protein of human SETD8 |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 5913% glycerol. Avoid freeze/thaw cycles. |
| Synonym | KMT5A,PR-Set7,SET07,SET8 |
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