| No | Size | Price | Availability | |
| ARP5764-61 | 50ul | 1500.00 | In Stock |  |
| ARP5764-61 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 5764 |
| Isotype: | IgG | Swiss Prot: | P21246 |
| purity: | Affinity purification |
| Background: |
| Pleiotrophin?(PTN) also known as?heparin-binding brain mitogen?(HBBM) or?heparin-binding growth factor 8?(HBGF-8) or?neurite growth-promoting factor 1?(NEGF1) or?heparin affinity regulatory peptide?(HARP) or?heparin binding growth associated molecule?(HB-GAM) is a?protein?that in humans is encoded by the?PTNgene.?Pleiotrophin is an 18-kDa?growth factor?that has a high affinity for?heparin. It is structurally related to?midkine?and?retinoic acid induced heparin-binding protein. Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation. |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB |
| Clonality | Polyclonal Antibody |
| Calculated MW | 19 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
|
| Immunogen | A synthetic peptide of humanPTN |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 5593% glycerol. Avoid freeze/thaw cycles. |
| Synonym | HARP, HBNF, HBGF8, NEGF1 |
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