Source: | Rabbit | Gene Id: | 3736 |
Isotype: | IgG | Swiss Prot: | Q09470 |
purity: | Affinity purification |
Background: |
This gene encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. The encoded protein has six putative transmembrane segments (S1-S6), and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif (GYGD). The functional channel is a homotetramer. The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting. Mutations in this gene have been associated with myokymia with periodic ataxia (AEMK). |
Reactivity | Human, Mouse, Rat |
Tested applications | WB IHC |
Clonality | Polyclonal Antibody |
Calculated MW | 56 kDa |
Recommended Dilutions |
WB 1:500-1:2000
IHC 1:50-1:100
|
Immunogen | A synthetic peptide of human KCNA1 |
Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 6081% glycerol. Avoid freeze/thaw cycles. |
Synonym | EA1, MK1, AEMK, HBK1, HUK1, MBK1, RBK1, KV1.1 |
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