Source: | Rabbit | Gene Id: | 6011 |
Isotype: | IgG | Swiss Prot: | Q15835 |
purity: | Affinity purification |
Background: |
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2). Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade. This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination. |
Reactivity | Human, Mouse, Rat |
Tested applications | WB IHC |
Clonality | Polyclonal Antibody |
Calculated MW | 64 kDa |
Recommended Dilutions |
WB 1:500-1:2000
IHC 1:50-1:200
|
Immunogen | A synthetic peptide of human GRK1 |
Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 6149% glycerol. Avoid freeze/thaw cycles. |
Synonym | RK, RHOK, GPRK1 |
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