| No | Size | Price | Availability | |
| ARP7535-63 | 50ul | 1500.00 | In Stock |  |
| ARP7535-63 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 7535 |
| Isotype: | IgG | Swiss Prot: | P43403 |
| purity: | Affinity purification |
| Background: |
| The Syk family protein tyrosine kinase Zap-70 is expressed in T and NK cells and plays a critical role in mediating T cell activation in response to T cell receptor (TCR) engagement (1). Following TCR engagement, Zap-70 is rapidly phosphorylated on several tyrosine residues through autophosphorylation and transphosphorylation by the Src family tyrosine kinase Lck (2-6). Tyrosine phosphorylation correlates with increased Zap-70 kinase activity and downstream signaling events. Expression of Zap-70 is correlated with disease progression and survival in patients with chronic lymphocytic leukemia (7,8). |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IHC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 70 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
IHC 1:50-1:200
|
| Immunogen | A recombinant protein of human ZAP70 |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | FLJ17670, FLJ17679, SRK, STD, TZK, ZAP-70 |
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