
| Source: | Rabbit | Gene Id: | 836 | 
| Isotype: | IgG | Swiss Prot: | P42574 | 
| purity: | Affinity purification | 
| Background: | 
| Caspase-3 (CPP-32, Apoptain, Yama, SCA-1) is a critical executioner of apoptosis, as it is either partially or totally responsible for the proteolytic cleavage of many key proteins such as the nuclear enzyme poly(ADP-ribose) polymerase (PARP) (1). Activation of caspase-3 requires proteolytic processing of its inactive zymogen into activated p17 and p12 fragments. Cleavage of caspase-3 requires aspartic acid at the P1 position (2). | 
| Reactivity | Human, Mouse, Rat | 
| Tested applications | WB IP | 
| Clonality | Polyclonal Antibody | 
| Calculated MW | 17 kDa;19 kDa;35 kDa | 
| Recommended Dilutions | WB 1:500-1:1000 | 
| Immunogen | A synthetic peptideof human CASP3 | 
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. | 
| Synonym | CASP3,CPP32,CPP32B,SCA-1,Caspase-3,APOPAIN | 
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