
| Source: | Rabbit | Gene Id: | 7297 | 
| Isotype: | IgG | Swiss Prot: | P29597 | 
| purity: | Affinity purification | 
| Background: | 
| Tyk2, a member of the Jak family of protein tyrosine kinases, associates with and is activated by receptors for many cytokines including IL-13, the IL-6 family, IL-10, and interferon-alpha and beta (1-3). Following ligand binding, Tyk2 is activated by phosphorylation on Tyr1054 and/or Tyr1055 (4). Tyk2 is required for the tyrosine phosphorylation of Stat3 in the IFN-beta signaling cascade (5). | 
| Reactivity | Human, Mouse, Rat | 
| Tested applications | WB IHC | 
| Clonality | Polyclonal Antibody | 
| Calculated MW | 134 kDa | 
| Recommended Dilutions | WB 1:500-1:2000 IHC 1:50-1:200 | 
| Immunogen | A recombinant protein of human TYK2 | 
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. | 
| Synonym | JTK1 | 
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