| No | Size | Price | Availability | |
| ARP5747-62 | 50ul | 1500.00 | In Stock |  |
| ARP5747-62 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 5747 |
| Isotype: | IgG | Swiss Prot: | Q05397 |
| purity: | Affinity purification |
| Background: |
| Focal adhesion kinase (FAK) is a widely expressed cytoplasmic protein tyrosine kinase involved in integrin-mediated signal transduction. It plays an important role in the control of several biological processes, including cell spreading, migration, and survival (1). Activation of FAK by integrin clustering leads to autophosphorylation at Tyr397, which is a binding site for the Src family kinases PI3K and PLCγ (2-5). Recruitment of Src family kinases results in the phosphorylation of Tyr407, Tyr576, and Tyr577 in the catalytic domain, and Tyr871 and Tyr925 in the carboxy-terminal region of FAK (6,7). |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IHC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 119 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
IHC 1:50-1:200
|
| Immunogen | A synthetic peptideof human PTK2 |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | FADK, FAK, FAK1, pp125FAK |
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