
| Source: | Rabbit | Gene Id: | 4318 | 
| Isotype: | IgG | Swiss Prot: | P14780 | 
| purity: | Affinity purification | 
| Background: | 
| The matrix metalloproteinases (MMPs) are a family of proteases that target many extracellular proteins including other proteases, growth factors, cell surface receptors and adhesion molecules (1). Among the family members, MMP-2, MMP-3, MMP-7 and MMP-9 have been characterized as important factors for normal tissue remodeling during embryonic development, wound healing, tumor invasion, angiogenesis, carcinogenesis and apoptosis (2-4). MMP activity correlates with cancer development (2). One mechanism of MMP regulation is transcriptional (5). Once synthesized, MMP exists as a latent proenzyme. Maximum MMP activity requires proteolytic cleavage to generate active MMPs by releasing the inhibitory propeptide domain from the full length protein (5). | 
| Reactivity | Human, Mouse, Rat | 
| Tested applications | WB IHC | 
| Clonality | Polyclonal Antibody | 
| Calculated MW | 78 kDa | 
| Recommended Dilutions | WB 1:500-1:2000 IHC 1:50-1:200 | 
| Immunogen | A synthetic peptideof human MMP9 | 
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. | 
| Synonym | CLG4B, GELB, MMP-9 | 
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