| No | Size | Price | Availability | |
| ARP1500-61 | 50ul | 1500.00 | In Stock |  |
| ARP1500-61 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 1500 |
| Isotype: | IgG | Swiss Prot: | O60716 |
| purity: | Affinity purification |
| Background: |
| Catenin δ-1 (p120 catenin) has an amino-terminal coiled-coil domain followed by a regulatory domain containing multiple phosphorylation sites and a central Armadillo repeat domain of ten linked 42-amino acid repeats. The carboxy-terminal tail has no known function (1). Catenin δ-1 fulfills critical roles in the regulation of cell-cell adhesion as it regulates E-cadherin turnover at the cell surface to determine the level of E-cadherin available for cell-cell adhesion (2). Catenin δ-1 has both positive and negative effects on cadherin-mediated adhesion (3). Actin dynamics are also regulated by catenin δ-1, which modulates RhoA, Rac, and cdc42 proteins (1). Analogous to β-catenin, catenin δ-1 translocates to the nucleus, although its role at this location is unclear. Many studies show that catenin δ-1 is expressed irregularly or is absent in various types of tumor cells, suggesting that catenin δ-1 may function as a tumor suppressor (4). Phosphorylation of Tyr904 on Catenin-δ-1 was identified at Cell Signaling Technology (CST) using PhosphoScan?, a CST's LC-MS/MS platform for phosphorylation site discovery (5). |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IHC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 105 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
IHC 1:50-1:200
|
| Immunogen | A recombinant protein of human CTNND1 |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | CAS, CTNND, KIAA0384, P120CAS, P120CTN, p120 |
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