| No | Size | Price | Availability | |
| ARP4193-63 | 50ul | 1500.00 | In Stock |  |
| ARP4193-63 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 4193 |
| Isotype: | IgG | Swiss Prot: | Q00987 |
| purity: | Affinity purification |
| Background: |
| MDM2, a ubiquitin ligase for p53, plays a central role in regulation of the stability of p53 (1). Akt-mediated phosphorylation of MDM2 at Ser166 and Ser186 increases its interaction with p300, allowing MDM2-mediated ubiquitination and degradation of p53 (2-4). Phosphorylation of MDM2 also blocks its binding to p19ARF, increasing the degradation of p53 (3). |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB |
| Clonality | Polyclonal Antibody |
| Calculated MW | 55 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
|
| Immunogen | A recombinant protein of human MDM2 |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | MDM2,HDMX,MGC5370,MGC71221,hdm2 |
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