| No | Size | Price | Availability | |
| ARP3558-62 | 50ul | 1500.00 | In Stock |  |
| ARP3558-62 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 3558 |
| Isotype: | IgG | Swiss Prot: | P60568 |
| purity: | Affinity purification |
| Background: |
| IL-2 is a T cell stimulatory cytokine best known for inducing T cell proliferation and NK cell proliferation and activation (1,2). IL-2 also promotes peripheral development of Treg cells (4, 5). Conversely, IL-2 is involved in activation induced cell death (AICD) that is observed post T cell expansion by increasing levels of Fas on CD4+ T cells (3). The effects of IL-2 are mediated through a trimeric receptor complex consisting of IL-2Rα, IL-2Rβ and the common gamma chain, γc (1,2). IL-2 Rα binds exclusively to IL-2 with low affinity and increases binding affinity of the whole receptor complex including IL-2Rβ and γc subunits. IL-2Rβ is also used by IL-15 (1,2). The common γc is used by other cytokines including IL-4, IL-7, IL-9, IL-15, and IL-21 (1,2). Binding of IL-2 initiates signaling cascades involving Jak1, Jak3, Stat5 and the PI3K/Akt pathways (1,2). |
| Reactivity | Human |
| Tested applications | WB IHC ICC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 18 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
IHC 1:50-1:200
ICC 1:100-1:200
|
| Immunogen | A recombinant protein of human IL2 |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | IL2,IL-2,TCGF,lymphokine |
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