| No | Size | Price | Availability | |
| ARP22933-63 | 50ul | 1500.00 | In Stock |  |
| ARP22933-63 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 22933 |
| Isotype: | IgG | Swiss Prot: | Q8IXJ6 |
| purity: | Affinity purification |
| Background: |
| Sirtuins are members of the NAD-dependent histone deacetylase family of proteins that participate in a variety of cellular functions, including histone deacetylation, gene silencing, chromosomal stability, and aging. SIRT2, a human homolog of the yeast SIR2 (silent information regulator-2), functions as transcriptional silencing mediator at mating-type loci, telomeres and ribosomal gene clusters. SIRT2 expression increases dramatically during mitosis and is multiply phosphorylated at the G(2)/M transition of the cell cycle. SIRT2 is part of a phosphorylation cascade where it is phosphorylated late in G(2), during M, and into the period of cytokinesis. Inhibition of SIRT2 is reported to rescue alpha-synuclein toxicity and modify inclusion morphology in a cellular model of Parkinson's disease (1-4). |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IHC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 43 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
IHC 1:50-1:200
|
| Immunogen | C term -peptideof human SIRT2 |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | SIRT2,SIR2,SIR2L,SIR2L2 |
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