| No | Size | Price | Availability | |
| ARP3667-63 | 50ul | 1500.00 | In Stock |  |
| ARP3667-63 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 3667 |
| Isotype: | IgG | Swiss Prot: | P35568 |
| purity: | Affinity purification |
| Background: |
| Insulin receptor substrate 1 (IRS-1) is one of the major substrates of the insulin receptor kinase (1). IRS-1 contains multiple tyrosine phosphorylation motifs that serve as docking sites for SH2-domain containing proteins that mediate the metabolic and growth-promoting functions of insulin (2-4). IRS-1 also contains over 30 potential serine/threonine phosphorylation sites. Ser307 of IRS-1 is phosphorylated by JNK (5) and IKK (6) while Ser789 is phosphorylated by SIK-2, a member of the AMPK family (7). The PKC and mTOR pathways mediate phosphorylation of IRS-1 at Ser612 and Ser636/639, respectively (8,9). Phosphorylation of IRS-1 at Ser1101 is mediated by PKCθ and results in an inhibition of insulin signaling in the cell, suggesting a potential mechanism for insulin resistance in some models of obesity (10). |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB |
| Clonality | Polyclonal Antibody |
| Calculated MW | 132 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
|
| Immunogen | A recombinant protein of human IRS1 |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | IRS1,HIRS-1 |
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