| No | Size | Price | Availability | |
| ARP3315-62 | 50ul | 1500.00 | In Stock |  |
| ARP3315-62 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 3315 |
| Isotype: | IgG | Swiss Prot: | P04792 |
| purity: | Affinity purification |
| Background: |
| Heat shock protein (HSP) 27 is one of the small HSPs that are constitutively expressed at different levels in various cell types and tissues. Like other small heat shock proteins, HSP27 is regulated at both the transcriptional and posttranslational levels (1). In response to stress, the expression level of HSP27 increases several-fold to confer cellular resistance to the adverse environmental change. HSP27 is phosphorylated at Ser15, Ser78 and Ser82 by MAPKAP kinase 2 as a result of the activation of the p38 MAP kinase pathway (2,3). Phosphorylation of HSP27 causes a change in its tertiary structure, which shifts from large homotypic multimers to dimers and monomers (4). It has been shown that phosphorylation and increased concentration of HSP27 modulates actin polymerization and reorganization (5,6). |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB |
| Clonality | Polyclonal Antibody |
| Calculated MW | 27 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
|
| Immunogen | A recombinant protein of human HSP27 |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | HSPB1,CMT2F,DKFZp586P1322,HMN2B,HS.76067,HSP27,HSP28,Hsp25,SRP27 |
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