| No | Size | Price | Availability | |
| ARP958-62 | 50ul | 1500.00 | In Stock |  |
| ARP958-62 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 958 |
| Isotype: | IgG | Swiss Prot: | P25942 |
| purity: | Affinity purification |
| Background: |
| CD40 Ligand (CD40L), a member of the TNF superfamily of ligands, is expressed as either a membrane-bound or soluble homotrimer (1). Both membrane-bound and soluble forms of CD40L have biological activity (1,2). CD40L is expressed primarily on activated T cells; however, mast cells, basophils, and NK cells may also express CD40L (1). CD40L functions as an important T cell co-stimulatory molecule and enhances T-dependent B cell responses (1,2). CD40L binds CD40, which is a receptor expressed on B cells, dendritic cells, and macrophages (1). Binding of CD40L to CD40 leads to the recruitment of TRAF proteins (TRAFs 2,3,5, and 6) resulting in the activation of the JNK and NF-κB pathways (1,2). |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB |
| Clonality | Polyclonal Antibody |
| Calculated MW | 31 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
|
| Immunogen | C term -peptideof human CD40 |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | CD40,Bp50,CDW40,MGC9013,TNFRSF5,p50 |
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