ELAVL2 + ELAVL4 Rabbit Polyclonal Antibody
No Size Price Availability  
YRP11748-01 50ul 1500.00 In Stock
YRP11748-01 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 19931996
Isotype: IgG Swiss Prot: Q12926,P25378
purity: Purified by Protein A.
Background:
The Elav-like genes encode for a family of RNA-binding proteins. Elav, a Drosophila protein and the first described member, is expressed immediately after neuroblastic differentiation into neurons and is necessary for neuronal differentiation and maintenance. Several mammalian Elav-like proteins, designated HuC, HuD and Hel-N1, are also expressed in postmitotic neurons. An additional mammalian homolog, HuR, which is also designated HuA, is ubiquitously expressed and is also overexpressed in a wide variety of tumors. Characteristically, these homologs all contain three RNA recognition motifs (RRM) and they specifically bind to AU-rich elements (ARE) in the 3'-untranslated region of mRNAs transcripts. ARE sites target mRNA for rapid degradation and thereby regulate the expression levels of genes involved in cell growth and differentiation. When Elav-like proteins associate with these ARE sites this degradation is inhibited, leading to an increased stability of the corresponding transcript. Elav proteins function within the nucleus, and they are shuttled between the nucleus and cytoplasm by a nuclear export signal, which is a regulatory feature of the Elav-like proteins as it limits their accessibility to ARE sites.
Reactivity Human, Mouse, Rat
Tested applications WB IHC IF
Clonality Polyclonal Antibody
Calculated MW /
Recommended Dilutions
WB 1:100-1:1000
IHC 1:100-1:500
IF 1:50-1:200
Immunogen KLH conjugated synthetic peptide derived from human ELAVL2
Storage Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20℃ for 12 months
Synonym ELAV like 4, ELAV like protein 2, ELAV like protein 4, ELAVL 2, ELAVL 4, HELN1, Hu antigen B, Hu antigen D, HUB, HUD, ELAV2_HUMAN, ELAV4_HUMAN.
This product is for research use only, not for diagnostic or therapeutic use!

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