| No | Size | Price | Availability | |
| ARP2550-62 | 50ul | 1500.00 | In Stock |  |
| ARP2550-62 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 2550 |
| Isotype: | IgG | Swiss Prot: | Q9UBS5 |
| purity: | Affinity purification |
| Background: |
| GABBR1 Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high- voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. Activated by (-)-baclofen, cgp27492 and blocked by phaclofen. Heterodimer of GABA-B-R1 and GABA-B-R2. Neither of which is effective on its own and homodimeric assembly does not seem to happen. Isoform 1E (without C-terminal intracellular domain) is unable to dimerize via a coiled-coil interaction with GABA-B-R2. Interacts with the leucine zipper of the C-terminal bZIP domain of ATF4 via its C-terminal region. Interacts with JAKMIP1. |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IF ICC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 108 kDa |
| Recommended Dilutions |
WB 1:500-1:1000
IF 1:100-1:500
ICC 1:100-1:500
|
| Immunogen | A synthetic peptide |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | GABA-B receptor, GABA-B receptor 1, GABA-B-R1, GABAB(1e), GABAB, subunit 1c, GABABR1, GABBR1-3, GABR1, gamma-aminobutyric acid type B receptor, subunit 1, Gb1, GPRC3A |
沪ICP备15003525号-1 Copyright ©, 2013-2022, Yihyson All Rights Reserved.
