Source: | Rabbit | Gene Id: | 5585 |
Isotype: | IgG | Swiss Prot: | Q16512 |
purity: | Affinity purification |
Background: |
The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq |
Reactivity | Human, Mouse, Rat |
Tested applications | WB |
Clonality | Polyclonal Antibody |
Calculated MW | 104 kDa |
Recommended Dilutions |
WB 1:500-1:1000
|
Immunogen | A synthetic peptide |
Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
Synonym | DBK, MGC46204, PAK1, PKN, PKN-ALPHA, PKN1, PRK1, PRKCL1, Protein kinase C-like 1, Protein kinase C-like PKN, protein kinase C-related kinase 1, protein kinase N1, Protein kinase PKN-alpha, Protein-kinase C-related kinase 1, serine-threonine kinase N, Seri |
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