| No | Size | Price | Availability | |
| ARP4638-61 | 50ul | 1500.00 | In Stock |  |
| ARP4638-61 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 4638 |
| Isotype: | IgG | Swiss Prot: | Q15746 |
| purity: | Affinity purification |
| Background: |
| This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts. [provided by RefSeq |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB |
| Clonality | Polyclonal Antibody |
| Calculated MW | 200 kDa |
| Recommended Dilutions |
WB 1:500-1:1000
|
| Immunogen | A synthetic peptide |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | KMLS, KRP, MLCK, MYLK, myosin light chain kinase, smooth muscle and non-muscle isozymes, myosin light polypeptide kinase, telokin |
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