| No | Size | Price | Availability | |
| ARP11221-61 | 50ul | 1500.00 | In Stock |  |
| ARP11221-61 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 11221 |
| Isotype: | IgG | Swiss Prot: | Q9Y6W6 |
| purity: | Affinity purification |
| Background: |
| Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique; it is evenly distributed in both the cytoplasm and the nucleus. This gene is widely expressed in various tissues and organs, and its expression is elevated by stress stimuli. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB |
| Clonality | Polyclonal Antibody |
| Calculated MW | 53 kDa |
| Recommended Dilutions |
WB 1:500-1:1000
|
| Immunogen | A synthetic peptide |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | dual specificity phosphatase 10, dual specificity phosphatase MKP-5, Dual specificity protein phosphatase 10, DUS10, DUSP10, MAP kinase phosphatase 5, Mitogen-activated protein kinase phosphatase 5, MKP-5, MKP5, serine/threonine specific protein phosphata |
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