Source: | Rabbit | Gene Id: | 3113 |
Isotype: | IgG | Swiss Prot: | P20036 |
purity: | Affinity purification |
Background: |
HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq |
Reactivity | Human |
Tested applications | WB |
Clonality | Polyclonal Antibody |
Calculated MW | 29 kDa |
Recommended Dilutions |
WB 1:500-1:1000
|
Immunogen | A synthetic peptide |
Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
Synonym | DP(W3), DP(W4), DPA1, HLA class II histocompatibility antigen, DP alpha 1 chain, HLA class II histocompatibility antigen, DP alpha chain, HLA-DP1A, HLA-DPA1, HLA-SB alpha chain, HLADP, HLASB, major histocompatibility complex, class II, DP alpha 1, MHC cl |
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