| No | Size | Price | Availability | |
| ARP11132-61 | 50ul | 1500.00 | In Stock |  |
| ARP11132-61 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 11132 |
| Isotype: | IgG | Swiss Prot: | Q9HC96 |
| purity: | Affinity purification |
| Background: |
| Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM) and located within the NIDDM1 region. Multiple alternative transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq |
| Reactivity | Human |
| Tested applications | WB |
| Clonality | Polyclonal Antibody |
| Calculated MW | 58 kDa |
| Recommended Dilutions |
WB 1:500-1:1000
|
| Immunogen | A synthetic peptide |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | calcium-activated neutral protease, Calcium-activated neutral proteinase 10, calpain 10, Calpain-10, CAN10, CANP 10, CAPN10, KIAA1845, NIDDM1 |
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