| No | Size | Price | Availability | |
| ARP1630-61 | 50ul | 1500.00 | In Stock |  |
| ARP1630-61 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 1630 |
| Isotype: | IgG | Swiss Prot: | P43146 |
| purity: | Affinity purification |
| Background: |
| This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009] |
| Reactivity | Human, Mouse, Rat |
| Tested applications | IF ICC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 158 kDa |
| Recommended Dilutions |
IF 1:100-1:500
ICC 1:100-1:500
|
| Immunogen | A synthetic peptide |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | colorectal cancer suppressor, deleted in colorectal carcinoma, netrin receptor DCC, tumor suppressor protein DCC |
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